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According to the most recent estimates from the World Health Organization (WHO), these are the diseases that cause the most deaths each year worldwide:

1. Coronary heart disease (heart attacks and heart artery disease)
2. Stroke
3. Chronic obstructive pulmonary disease (COPD)
4. Lower respiratory infections (such as pneumonia)
5. COVID-19* (during the pandemic years, it was among the leading causes)
6. Cancer of the trachea, bronchus, and lung
7. Diabetes mellitus
8. Alzheimer's disease and other dementias
9. Chronic kidney disease
10. Tuberculosis

Diseases with the highest mortality rates by type:
Cardiovascular diseases (the deadliest):
Heart attack.
Stroke.
Hypertension and other diseases of the circulatory system.

Together, they cause millions of deaths each year, making them the leading cause of death worldwide.

Deadliest Cancers
Lung cancer.
Liver cancer.
Colon and rectal cancer.
Stomach cancer.
Breast cancer.
Infectious Diseases That Cause the Most Deaths
Tuberculosis.
HIV/AIDS.
Malaria.
Pneumonia.
COVID-19 (during peak years).
Aging-Related Diseases
Alzheimer's.
Other dementias.
Parkinson's (to a lesser extent).
Main Risk Factors
Many of these diseases are linked to preventable factors such as:

Smoking.
High blood pressure.
Diabetes.
High cholesterol.
Obesity.
Sedentary lifestyle.
Unhealthy diet.
Excessive alcohol consumption. Air pollution.
Together, these factors significantly increase the risk of developing cardiovascular disease, cancer, diabetes, and respiratory illnesses, which account for the majority of deaths worldwide.